02-P012 What role does canonical Wnt signalling play in development and tumourigenesis of the cerebellar granule cell population?

the A8, and it has been shown that the gene double sex (dsx) represses growth in the former, probably by repressing decapentaplegic (dpp) expression. We show here that the absence of Abd-B or homothorax (hth) in this segment also increases growth and activates the expression of dMyc and dpp. The effects on the size of the A9 can be rescued if dpp activity is reduced. Neither Abd-B, dsx, nor hth regulates each other’s expression, which suggest that dsx, hth and Abd-B may coordinately repress growth in this primordium of the genital disc.